This section presents a curated database of genetic polymorphisms and regulatory variants associated with the NRF2 gene (NFE2L2) and its downstream Antioxidant Response Elements (AREs) located in NRF2-target genes. The accompanying Excel file
compiles experimentally validated single nucleotide polymorphisms (SNPs), promoter variants, and functional allelic changes that influence NRF2 expression or transcriptional activity. These variants are organized according to their genomic position, allele frequency, functional annotation, and reported associations with pathological conditions.
The resource provides a molecular basis for understanding interindividual variability in NRF2 pathway activation and its consequences for susceptibility to oxidative stress-related diseases, including cancer, neurodegeneration, metabolic disorders, and cardiovascular pathologies. It also highlights genetic variants within ARE sequences that may modulate target gene responsiveness to NRF2 activation, supporting integrative analyses between genomics, transcriptomics, and pharmacogenomics.
By consolidating dispersed information into a unified, accessible format, this database strengthens the technological platform of BenBedPhar and supports the Action’s goal of developing harmonized molecular resources for translational NRF2 research. It serves as a reference for genotype-phenotype association studies, biomarker development, and precision medicine approaches centered on NRF2-regulated mechanisms.
