Recent Advances in Extracellular-Intracellular Communication and Cancer Therapies
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 31 July 2025
Special Issue Editor
Dr. Ana Rita Carlos E-Mail Website
Guest Editor
E3c-CHANGE, Department of Animal Biology, Faculty of Sciences, University of Lisbon, 1749-016 Lisbon, Portugal
Interests: extracellular-intracellular communication; disease mechanisms; oxidative stress; DNA damage; cancer; gene therapy
Special Issue Editor
Dear Colleagues,
The extracellular matrix (ECM) serves as an important scaffold for cell growth, proliferation, differentiation, and migration. However, the role of ECM in cell homeostasis goes far beyond structural mechanisms, extending to important ECM–cell communication and mediating cell–cell signaling. Taking this into account, in recent years, the importance of ECM in cancer progression has gained increasing interest. Exploring how extracellular–intracellular communication impacts cancer onset and progression is a key line of research, both in fundamental biology and in translational research.
In this Special Issue, we aim at highlighting studies of excellence that focus on at least one of the following aspects:
- ECM role on cancer onset and progression;
- ECM–cell communication in cancer;
- Impact of integrin-mediated signaling and cytoskeleton;
- ECM crosstalk with oxidative stress and DNA damage;
- Latest advances on cancer therapies focused on ECM–cell communication.
Together, this Special Issue is expected to raise awareness for an essential player in cancer: the ECM.
For this Special Issue, we invite authors as well as the participants of The COST Action CA20121 to submit novel work or reviews establishing the importance of oxidative stress in Extracellular-Intracellular Communication and Cancer Therapies.
Dr. Ana Rita Carlos
Guest Editor
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