Special Issue “Crosstalk Between Oxidative Stress and Inflammation in Cardiovascular Diseases, Cancer and Neurodegeneration”


Crosstalk Between Oxidative Stress and Inflammation in Cardiovascular Diseases, Cancer and Neurodegeneration

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section “Health Outcomes of Antioxidants and Oxidative Stress“.

Deadline for manuscript submissions: 30 November 2023

Special Issue Editors

Dr. Adrian Manea
Guest Editor

Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, 050568 Bucharest, Romania
Interests: cardiovascular diseases; atherosclerosis; diabetes; hypertension; redox biology; inflammation; transcriptomics; epigenetics

Dr. Gina Manda
Guest Editor

“Victor Babeș” National Institute of Pathology, Splaiul Independentei 99-101, 050096 Bucharest, Romania
Interests: redox biology; NRF2 medicine and therapeutics; immune response; neurodegeneration; cancer; radiotherapy

Special Issue Information

Dear Colleagues,

Extensive evidence demonstrates that many chronic diseases and cancer have a background of chronic low-grade inflammation and redox disturbances that precede the onset of overt symptoms and accompany the disease during its progression. In depth knowledge on the crosstalk of genetic determinants, epigenetic mechanisms and critical transcription factors in inflammation and redox signaling, such as NFkB, AP1 and NRF2, and their interference with various other signaling pathways involved in DNA repair, endoplasmic reticulum stress, autophagy and hypoxia, as well as an integrative analysis of recently generated omics big data, is expected to foster the development of innovative therapeutic strategies for controlling disease in its early stages or as preventive measure for at risk patients. Considering the limitations of the current anti-inflammatory and antioxidant therapies in chronic pathologies, a major research priority is to simultaneously target chronic inflammation and redox disturbances by manipulating signaling pathways, such as the NRF2/KEAP1 axis.

This Special Issue is focused on the current state of the art of preclinical and clinical studies on the inflammation–redox interplay in ageing and related chronic diseases, such as neurodegeneration and cardiovascular, metabolic and immune disorders, as well as in cancer. We invite researchers and clinicians across the globe to submit their contributions (original articles, reviews, systematic reviews, meta-analyses or perspectives relevant to the scope of the Special Issue, including, but not limited to, the following: inflammation; inflammasomes; redox biology; transcription factors; NRF2; epigenetics; aging; cardiovascular pathology; neurodegeneration; macular degeneration; and cancer.

Dr. Adrian Manea
Dr. Gina Manda
Guest Editors

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