Advances in Nrf2 Signaling Pathway in Neurodegenerative Diseases
Submission Deadline: 20 January 2026
Guest Editors
Email: brigitta.buttari@iss.it
Affiliation: Department of Cardiovascular, Endocrine-Metabolic Diseases, and Aging, Italian National Institute of Health, 00161, Rome, Italy
Research Interests: Nrf2 signaling, non-communicable diseases, oxidative stress, immunology, proteostasis, antioxidant response, therapeutic targets
Email: sarmistha_pharmacol@yahoo.com
Affiliation: Department of Biotechnology, Institute of Applied Science and Humanities, GLA University, Mathura 281406, Uttar Pradesh, India
Research Interests: Nrf2 Signaling, oxidative stress, inflammation, redox signaling, natural products
Summary
Nrf2 (NF-E2-related factor 2) is a vital member of the Cap’n’collar (CNC) transcription factor family. It plays a significant role in various biological processes, including redox signaling, the metabolism of xenobiotics, carbohydrates, lipids, and iron. Additionally, Nrf2 is crucial for activating antioxidant responses and modulating anti-inflammatory responses. This special issue aims to explore the complex molecular pathways that govern the NRF2 signaling pathway, with a strong emphasis on uncovering the fundamental mechanisms behind neuronal degeneration.
Key areas of focus include, but are not limited to:
1. Exploring the Integral Role of Nrf2 in Aging, Alzheimer’s Disease, and Other Neurodegenerative Disorders.
2. Enhancing Proteostasis: The Positive Impact of the Transcription Factor Nrf2 on Neurodegenerative Diseases.
3. Nrf2: A Promising Therapeutic Target for Addressing Neurodegenerative Disorders.
4. Investigating Ferroptosis and Nrf2: Collaborative Factors in the Fight Against Alzheimer’s Disease.
5. Developing Biomarkers of Nrf2 Signaling: Advancing Our Understanding of Neurodegenerative Processes.
6. Examining the Relationship Between Aging, Nrf2, and Tau: Insights into Neurodegeneration.
7. Utilizing Natural Bioactive Molecules: A Constructive Strategy for the Treatment and Prevention of Neurodegenerative Diseases.
We invite cutting-edge original research articles, comprehensive reviews, and insightful perspectives that examine the complex molecular pathways of the NRF2 signaling pathway, focusing on the key mechanisms behind neuronal degeneration. In particular, we welcome contributions from authors and participants of the COST Action CA20121, who can offer novel work or reviews highlighting the importance of these pathways during neuronal degeneration. By showcasing the most recent breakthroughs and addressing pressing challenges in this field, this special issue aspires to ignite the development of innovative therapeutic strategies and clinically relevant biomarkers, with the potential to significantly alter disease progression.
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