This is a structured registry of validated cellular and animal models designed to investigate the biological and pharmacological roles of NRF2 across major non-communicable diseases (NCDs). The registry compiles advanced models that accurately reflect NRF2-dependent mechanisms involved in oxidative stress, inflammation, and metabolic regulation. It integrates preclinical systems from diverse disease contexts, including cardiovascular, neurodegenerative, hepatic, pulmonary, and metabolic disorders, thereby providing a unified resource to support translational research and pharmacological testing.
This registry aligns directly with BenBedPhar’s core objectives of harmonization, reproducibility, and translational applicability of NRF2-focused studies. It catalogues in vitro and in vivo systems with proven molecular fidelity and predictive value for therapeutic screening, thus enabling standardized evaluation of NRF2 modulators across laboratories and disease domains.
Recent publications such as
“NRF2 modulation in neurodegenerative diseases: Preclinical advances and translational perspectives” (Free Radical Biology and Medicine, 2024)
https://www.sciencedirect.com/science/article/pii/S2213231724004427?via%3Dihub
and
“Experimental models for NRF2-related drug discovery: From cellular systems to integrated animal approaches” (Redox Biology, 2025)
https://www.sciencedirect.com/science/article/pii/S2213231725003660?via%3Dihub
exemplify the type of scientific evidence underpinning this deliverable. These works demonstrate the increasing sophistication of NRF2-related model systems and their central role in elucidating disease mechanisms and therapeutic responses.
Collectively, this registry enhances the technological platform of BenBedPhar, providing researchers with a curated and interoperable catalogue of superior models to accelerate NRF2-centered pharmacological innovation and facilitate cross-disease translational investigations.
