International Women’s Day!
Empowering Women in Science: Spotlighting Their Role in Research
In our ongoing COST action “Bench to Bedside transition for Pharmacological regulation of NRF2 in non-communicable diseases,” we aim to shine a light on the invaluable contributions of women in the field of science. With a commitment to gender equality and recognizing the significant role women play in advancing scientific knowledge, we have meticulously curated a selection of scientific works published in 2023, all led by women.
The focus of our attention lies on the transcription factor NRF2, a critical player in the regulation of various non communicable diseases.
Throughout our exploration, we’ve identified numerous studies where women have taken the lead, serving as either the first author or corresponding author. These women have demonstrated exceptional expertise, dedication, and innovation in unraveling the complexities surrounding NRF2 and its implications for human health.
By highlighting the work of these remarkable women, we seek to inspire and empower future generations of female scientists. Their leadership, ingenuity, and groundbreaking research underscore the indispensable role of women in driving scientific progress and innovation.
As we continue to champion diversity and inclusivity in science, we invite you to join us in celebrating the remarkable achievements of women in the field of NRF2 research. Together, let us foster an environment where every voice is heard and every contribution is valued, paving the way for a brighter, more equitable future in science.
Birsen Can Demirdöğen lab
NRF2-related contributions
Reis-Mendes A, Ferreira M, Padrão AI, Duarte JA, Duarte-Araújo M, Remião F, Carvalho F, Sousa E, Bastos ML, Costa VM. The Role of Nrf2 and Inflammation on the Dissimilar Cardiotoxicity of Doxorubicin in Two-Time Points: a Cardio-Oncology In Vivo Study Through Time. Inflammation. 2023 Oct 14. PMID: 37833616.
Yang F, Smith MJ, Griffiths A, Morrell A, Chapple SJ, Siow RCM, Stewart T, Maret W, Mann GE. Vascular protection afforded by zinc supplementation in human coronary artery smooth muscle cells mediated by NRF2 signaling under hypoxia/reoxygenation.
Redox Biol. 2023 Aug; PMID: 37315344;
Paramonova’s lab, Latvia (left) and Georgiev`s lab, Bulgaria (right)
Elbaset MA, Mohamed BMSA, Hessin A, Abd El-Rahman SS, Esatbeyoglu T, Afifi SM, Fayed HM. Nrf2/HO-1, NF-κB and PI3K/Akt signalling pathways decipher the therapeutic mechanism of pitavastatin in early phase liver fibrosis in rats. J Cell Mol Med. 2024 Jan 12. PMID: 38214394.
Kuntic I, Kuntic M, Oelze M, Stamm P, Karpi A, Kleinert H, Hahad O, Münzel T, Daiber A. The role of acrolein for E-cigarette vapour condensate mediated activation of NADPH oxidase in cultured endothelial cells and macrophages. Pflugers Arch. 2023 Jul;475(7):807-821. PMID: 37285062.
Yang F, Smith MJ. Metal profiling in coronary ischemia-reperfusion injury: Implications for KEAP1/NRF2 regulated redox signaling. Free Radic Biol Med. 2024 Jan;210:158-171. PMID: 37989446.
Dayalan Naidu S, Dinkova-Kostova AT. Omaveloxolone (SkyclarysTM) for patients with Friedreich’s ataxia. Trends Pharmacol Sci. 2023 Jun;44(6):394-395. PMID: 37142519.
Luo Y, Chatre L, Melhem S, Al-Dahmani ZM, Homer NZM, Miedema A, Deelman LE, Groves MR, Feelisch M, Morton NM, Dolga A, van Goor H. Thiosulfate sulfurtransferase deficiency promotes oxidative distress and aberrant NRF2 function in the brain. Redox Biol. 2023 Dec;68:102965. PMID: 38000344.
Dayalan Naidu S, Angelova PR, Knatko EV, Leonardi C, Novak M, de la Vega L, Ganley IG, Abramov AY, Dinkova-Kostova AT. Nrf2 depletion in the context of loss-of-function Keap1 leads to mitolysosome accumulation. Free Radic Biol Med. 2023 Nov 1;208:478-493. PMID: 37714439.
Silva-Llanes I, Shin CH, Jiménez-Villegas J, Gorospe M, Lastres-Becker I. The Transcription Factor NRF2 Has Epigenetic Regulatory Functions Modulating HDACs, DNMTs, and miRNA Biogenesis. Antioxidants (Basel). 2023 Mar 4;12(3):641. PMID: 36978889.
Sorice M, Profumo E, Capozzi A, Recalchi S, Riitano G, Di Veroli B, Saso L, Buttari B. Oxidative Stress as a Regulatory Checkpoint in the Production of Antiphospholipid Autoantibodies: The Protective Role of NRF2 Pathway. Biomolecules. 2023 Aug 5;13(8):1221. doi: 10.3390/biom13081221. PMID: 37627286; PMCID: PMC10452087.
Feng J, Read OJ, Dinkova-Kostova AT. Nrf2 in TIME: The Emerging Role of Nuclear Factor Erythroid 2-Related Factor 2 in the Tumor Immune Microenvironment. Mol Cells. 2023 Mar 31;46(3):142-152. doi: 10.14348/molcells.2023.2183. Epub 2023 Mar 17. PMID: 36927604; PMCID: PMC10070167.
Reis-Mendes A, Ferreira M, Duarte JA, Duarte-Araújo M, Remião F, Carvalho F, Sousa E, Bastos ML, Costa VM. The role of inflammation and antioxidant defenses in the cardiotoxicity of doxorubicin in elderly CD-1 male mice. Arch Toxicol. 2023 Dec;97(12):3163-3177. doi: 10.1007/s00204-023-03586-1. Epub 2023 Sep 7. PMID: 37676301; PMCID: PMC10567829.
Brackhan M, Arribas-Blazquez M, Lastres-Becker I. Aging, NRF2, and TAU: A Perfect Match for Neurodegeneration? Antioxidants (Basel). 2023 Aug 4;12(8):1564. doi: 10.3390/antiox12081564. PMID: 37627559; PMCID: PMC10451380.
Buttari’s lab, Sapienza University of Rome, Italy
With tireless dedication and unwavering commitment, our researchers are immersed in a multitude of scientific pursuits.
From unraveling the mysteries of molecular pathways to exploring innovative treatment modalities, their work spans a diverse array of disciplines and fields.
Behind the scenes, our scientists labor tirelessly, driven by a shared passion for advancing knowledge and improving lives.
Through their collective efforts, they strive to push the boundaries of scientific understanding and pave the way for transformative breakthroughs.
